ingrid_STO said:

The OASIS programme put 50mg oral in the same territory as 2.4mg injectable — around 15% mean weight loss — but it needed a dose 20 times larger to…

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

That is the short version; the long version is somebody else's post.

BariatricNurseD said:

Read four things before the headline number.

This is where I part company with the consensus forming above. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

That is the short version; the long version is somebody else's post.

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.