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ForumsPublic SquareNovo Nordisk CagriSema Phase 3 results — need advice Page 7

Novo Nordisk CagriSema Phase 3 results — need advice

mike_mod Tue, Nov 18, 2025 at 8:31 PM 43 replies 1,982 viewsPage 7 of 9
CarlaRPh_TPA
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Dec 1, 2025 at 12:07 AM#31

Following on from rachel_ABQ — and this may be the naive question:

What would you measure differently if you were starting again?

43 18FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 40 others
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LarryQC_SD
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Dec 1, 2025 at 10:03 PM#32
mike_mod said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

42 17paul_denver, TinaHashiRN, robert_kc and 39 others
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RickReta_CO
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Dec 2, 2025 at 8:00 PM#33
mike_mod said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

41 16hyun_seoul, jim_asheville, matt_MKE and 38 others
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Dr.GutHealth
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Dec 3, 2025 at 5:57 PM#34
mike_mod said:
Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

40 15Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 37 others
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Dr.RaviCardio
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Dec 4, 2025 at 3:55 PM#35

Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

Last edited: Dec 4, 2025 at 4:55 PM
39 14jason_sac26, chris_chi24, tampaLisa73 and 36 others
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