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ForumsCardiovascular OutcomesNNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison Page 6

NNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison

BiostatsBrad Tue, May 19, 2026 at 12:55 AM 26 replies 690 viewsPage 6 of 6
jason_sac26
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May 31, 2026 at 11:30 PM#26
stefan_berlin said:
Say what you would expect to see if you were wrong, before you look.

That reframing is the part I needed.

Last edited: Jun 1, 2026 at 1:30 AM
11 11pete_RVA, CarlaRPh_TPA, steph_laguna and 8 others
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Dr.BariatricHTX
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Jun 2, 2026 at 1:35 PM#27

Adding the clinical framing, because it changes how the question reads. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

10 10pete_RVA, CarlaRPh_TPA, steph_laguna and 7 others
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anders_CPH
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Jun 4, 2026 at 3:40 AM#28
Dr.BariatricHTX said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Second this.

9 9AussieAnna, BethLabQueen, ChrisMacros and 6 others
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LibrarianMeg
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Jun 5, 2026 at 5:43 PM#29
Dr.BariatricHTX said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

There is a second half to this that has not been said yet. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Correct me if the detail matters more than I have assumed.

Last edited: Jun 5, 2026 at 7:43 PM
8 8JessicaM_2024, TomFromTexas, mike.trainer_LA and 5 others
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BiostatsBrad
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Jun 7, 2026 at 7:45 AM#30

Closing the loop on my own question.

Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me. I was escalating because the number was available, not because I had stopped responding.

Last edited: Jun 7, 2026 at 8:45 AM
36 11NicoleRaleigh, james_edin, FranDenver and 33 others
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