Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
ingrid_STO said:The mechanism and the magnitude are separate questions.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
ingrid_STO said:The mechanism and the magnitude are separate questions.
ingrid_STO has the substance of this right. The condition it depends on is worth stating. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
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View Resultsingrid_STO said:The mechanism and the magnitude are separate questions.
That reframing is the part I needed. Printing the relevant bit and taking it with me.