NurseKim_ATL said:

DoseLogDan said: ...cardiovascular risk is just another fad...

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 12 months of treatment.

The 5 criteria (and my journey):

1. Waist circumference: 51" → 37" ✅ Resolved
2. Triglycerides: 247 → 107 ✅ Resolved
3. HDL: 35 → 59 ✅ Resolved
4. Blood pressure: 147/93 → 120/74 ✅ Resolved
5. Fasting glucose: 127 → 87 ✅ Resolved

Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.

NurseKim_ATL said:

DoseLogDan said: ...cardiovascular risk is just another fad...

Lp(a) and cardiovascular risk: a nuance that matters. Unlike most lipid markers, Lp(a) is 90%+ genetically determined and doesn't really change with weight loss or GLP-1 therapy.

My Lp(a) has remained at 75 nmol/L across all time points. If yours is elevated (>50 nmol/L), you need additional risk mitigation strategies regardless of your GLP-1 response. Don't assume your medication is covering all cardiovascular risk factors.

One thing that is still open after NurseKim_ATL’s answer:

Was that from a primary source or from a summary of one?

kate.chem said:

Lp(a) and cardiovascular risk: a nuance that matters.

NNT calculation for cardiovascular risk clinical endpoints: NNT = 1/ARR (absolute risk reduction).

From SELECT trial: MACE at 39 months — 6.5% semaglutide vs 8.0% placebo. ARR = 1.5%. NNT = 67 over 3.3 years.

Compare to established therapies:

These NNTs are clinically meaningful and comparable to accepted cardiovascular interventions.

kate.chem said:

Lp(a) and cardiovascular risk: a nuance that matters.

kate.chem said:

...we're creating a generation dependent on cardiovascular risk...

I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?

Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.

If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.