From the other side of the consultation, briefly.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 3.9% to 8.4% over 8 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

From the other side of the consultation, briefly.

Comprehensive lipid panel update relevant to the lipid panel:

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

Dr.SleepRoch said:

Comprehensive lipid panel update relevant to the lipid panel: Marker Baseline 6 Months 12 Months Reference Total Cholesterol 237 212 182 <200 LDL…

Same pattern here, and in the same order. Posting only so the count is not one.

Dr.SleepRoch said:

Comprehensive lipid panel update relevant to the lipid panel: Marker Baseline 6 Months 12 Months Reference Total Cholesterol 237 212 182 <200 LDL…

Coming at Dr.SleepRoch’s question from a different direction. SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1. Different trials, different populations, so the comparison is indicative rather than decisive — but SURPASS-2 was a genuine head-to-head and it pointed the same way.

Moderator note: a couple of off-topic posts removed.