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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesSELECT trial: 20% MACE reduction — looking for input Page 4

SELECT trial: 20% MACE reduction — looking for input

TinaHashiRN Sun, Jan 4, 2026 at 9:06 AM 29 replies 1,384 viewsPage 4 of 6
MeganSA_TX
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San Antonio, TX
Jan 5, 2026 at 6:41 AM#16
Dr.DermMIA said:
Lp(a) and cardiovascular risk: a nuance that matters.

Mine went the same way, slower.

Last edited: Jan 5, 2026 at 8:41 AM
13 13PharmD_Rodriguez, julia.endo, JessicaM_2024 and 10 others
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KetoKyle
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Jul 2024
Utah
Jan 5, 2026 at 8:45 AM#17
Dr.PeteFamMed said:
SUSTAIN-6 was the first CVOT to show cardiovascular benefit with semaglutide, relevant to cardiovascular risk.

Same pattern here, and in the same order. Nothing to add that would improve it.

12 12JenMemphis, pat_auckland, Dr.GastroMayo and 9 others
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Dr.GutHealth
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Jan 5, 2026 at 10:49 AM#18
Dr.PeteFamMed said:
SUSTAIN-6 was the first CVOT to show cardiovascular benefit with semaglutide, relevant to cardiovascular risk.

Dizziness and cardiovascular risk: I was lightheaded for the first 3 weeks. Root cause was a combination of reduced caloric intake and mild dehydration.

Fix: minimum 80-100oz water daily, don't skip meals even if you're not hungry (eat small protein-rich snacks), and stand up slowly from sitting/lying positions. Also check your blood pressure — GLP-1-induced weight loss can make BP meds too strong, requiring dose reduction.

11 11jennifer_SEA, tyler_CSCS, VanRx_Mike and 8 others
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quinn_sf
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Jun 2024
San Francisco, CA
Jan 5, 2026 at 12:53 PM#19
Dr.PeteFamMed said:
SUSTAIN-6 was the first CVOT to show cardiovascular benefit with semaglutide, relevant to cardiovascular risk.

Senior perspective on cardiovascular risk: I'm 68 years old and started this journey skeptically. My cardiologist recommended it after years of failed interventions.

14 months later: down 36 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

Last edited: Jan 5, 2026 at 6:53 PM
10 10andrew_nyc, Dr.EndoEP, GraceAZ_72 and 7 others
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mike_mod
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Jan 5, 2026 at 2:57 PM#20

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.

38 13PurityPaulOR, MaxMetOK, MounjBrad and 35 others
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