Dec 21, 2025 at 7:04 AM#26
One thing that is still open after KevinCompounds’s answer:
What did you change at the same time, and can you separate the two now?
22 22DoseLogDan, SleepFixSam, PurityPaulOR and 19 others
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Dec 21, 2025 at 1:24 PM#27
SleepDoc_PDX said:KevinCompounds said: ...we're creating a generation dependent on cardiovascular risk...
SleepDoc_PDX said:...we don't know the long-term effects of cardiovascular risk...
This is a fair point, and I think intellectual honesty requires acknowledging it. GLP-1 agonists in their current form have ~8-10 years of human exposure data. That's not nothing, but it's not 30+ years either.
However: the risk-benefit calculation should also consider the KNOWN long-term effects of untreated obesity — diabetes, cardiovascular disease, cancer, joint destruction, reduced lifespan by 5-10 years.
Uncertainty about GLP-1 long-term safety vs certainty about obesity consequences. The calculus seems clear to me, but reasonable people can disagree.
Last edited: Dec 21, 2025 at 5:24 PM
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Dec 21, 2025 at 7:44 PM#28
SleepDoc_PDX said:KevinCompounds said: ...we're creating a generation dependent on cardiovascular risk...
I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.
My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.
16 months later: down 63 lbs, off metoprolol, A1C from 8.6% to 5.2%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.
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Browse GL BiochemDec 22, 2025 at 2:04 AM#29
SleepDoc_PDX said:KevinCompounds said: ...we're creating a generation dependent on cardiovascular risk...
Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.
19 19Dr.MetabolicMD, RetaRick_CA, JenPlateau and 16 others
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Dec 22, 2025 at 8:24 AM#30
NurseLeah_Nash said:I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.
6 month update on cardiovascular risk: down 47 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
47 22JenMemphis, pat_auckland, Dr.GastroMayo and 44 others
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