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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — what worked for you? Page 2

Lp(a) on GLP-1 agonists — what worked for you?

emma_london Tue, Dec 9, 2025 at 11:07 AM 11 replies 1,197 viewsPage 2 of 3
FDA_TrackerJim
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Rockville, MD
Dec 9, 2025 at 12:53 PM#6
HPLC_Greg said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Dec 9, 2025 at 3:53 PM
5 8Dr.Martinez, mike_mod, SarahChen_PharmD and 2 others
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PeptideChemSF
Senior Member
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Jan 2024
San Francisco, CA
Dec 9, 2025 at 1:34 PM#7
emma_london said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Comprehensive lipid panel update relevant to the lipid panel:

MarkerBaseline6 Months12 MonthsReference
Total Cholesterol259204184<200
LDL154139104<100
HDL475461>40
Triglycerides279194104<150
LDL-P16991249949<1000

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

6 9dave_SLC, FDA_TrackerJim, ricardo_MIA and 3 others
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sarah_TO
Member
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Sep 2024
Toronto, CA
Dec 9, 2025 at 2:15 PM#8
FDA_TrackerJim said:
Careful with treating an unchanged LDL-C as a failure.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P17101010Particle count (more precise than LDL-C)
Small dense LDL55%34%Atherogenic pattern
Remnant cholesterol3814Triglyceride-rich lipoproteins
oxLDL7538Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

7 10GraceAZ_72, carl_compliance, DanielChem_CHI and 4 others
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matt_MKE
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Sep 2024
Milwaukee, WI
Dec 9, 2025 at 2:56 PM#9

Following on from Dr.CardioMD — and this may be the naive question:

Was that from a primary source or from a summary of one?

Last edited: Dec 9, 2025 at 5:56 PM
8 11carl_compliance, DanielChem_CHI, marco_milano and 5 others
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emma_london
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London, UK
Dec 9, 2025 at 6:14 PM#10

Closing the loop on my own question.

For the archive: it took about six weeks rather than the two I expected, and the difference between those two numbers was the whole of my problem.

14 14julia.endo, JessicaM_2024, TomFromTexas and 11 others
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