🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersLiver enzymes trending down on GLP-1 — ALT/AST normalization Page 3

Liver enzymes trending down on GLP-1 — ALT/AST normalization

MASHdoc_SA Sun, Jun 7, 2026 at 5:07 PM 17 replies 389 viewsPage 3 of 4
SandraNC_45
Member
312
1,345
Sep 2024
Charlotte, NC
Jun 8, 2026 at 6:09 AM#11
Dr.EndoIndy said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

48 23FranDenver, Dr.BariatricHTX, LindaRN_retired and 45 others
Reply Quote Save Share Report
Dr.PeteFamMed
Senior Member
2,012
9,234
Jan 2024
Minneapolis, MN
Jun 8, 2026 at 7:52 AM#12

Clinical perspective, offered as context rather than as advice. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

47 22tommy_boulder, hyun_seoul, jim_asheville and 44 others
Reply Quote Save Share Report
Dr.SurgeonPGH
Senior Member
1,345
6,789
Mar 2024
Pittsburgh, PA
Jun 8, 2026 at 9:35 AM#13
Dr.ReproEndo said:
NASH/MAFLD therapeutic landscape and liver and MASH: GLP-1 agonists are emerging as potential first-line NASH therapy.

I read this differently from Dr.ReproEndo, on substance rather than tone. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Last edited: Jun 8, 2026 at 12:35 PM
46 21PharmHunterJen, TomTeleRx, DoseLogDan and 43 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
Jun 8, 2026 at 11:18 AM#14

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Jun 8, 2026 at 1:18 PM
45 20B12Beth, RickReta_CO, PharmHunterJen and 42 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Jun 8, 2026 at 1:00 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

44 19PurityPaulOR, MaxMetOK, MounjBrad and 41 others
Reply Quote Save Share Report

Similar Threads

Optimal lab testing frequency on GLP-1 — evidence-based schedule5 replies
A1C from 7.2 to 5.1 — my bloodwork transformation19 replies
Thyroid function monitoring on GLP-1 — TSH and free T4 trends3 replies
Lipid panel improvements mega-thread — share your numbers19 replies
Kidney function on semaglutide — eGFR and UACR improvements21 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register