PeptideSynthNJ said:

Senior perspective on cardiovascular risk: I'm 69 years old and started this journey skeptically.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off amlodipine entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.

PeptideSynthNJ said:

Senior perspective on cardiovascular risk: I'm 69 years old and started this journey skeptically.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

SleepDoc_PDX said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Second this.

SleepDoc_PDX said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at SleepDoc_PDX’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.