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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHas anyone dealt with tirzepatide cardiovascular safety? Page 5

Has anyone dealt with tirzepatide cardiovascular safety?

carlos_SATX Thu, Sep 18, 2025 at 10:20 PM 41 replies 1,657 viewsPage 5 of 9
DadBodDave
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Sep 21, 2025 at 9:31 PM#21
BiostatsBrad said:
Practical: whatever you change, write down the date and the reason.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Last edited: Sep 22, 2025 at 12:31 AM
3 3laura_annarbor, JenMemphis, pat_auckland
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VanRx_Mike
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Sep 22, 2025 at 4:28 PM#22
BiostatsBrad said:
Practical: whatever you change, write down the date and the reason.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

Last edited: Sep 22, 2025 at 7:28 PM
2 2MikeNYC_runner
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sarah_TO
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Sep 23, 2025 at 11:25 AM#23
BiostatsBrad said:
Practical: whatever you change, write down the date and the reason.

That reframing is the part I needed. Adding it to my notes with a link back to this thread.

Last edited: Sep 23, 2025 at 3:25 PM
1 1GraceAZ_72
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Dr.NutriCornell
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Sep 24, 2025 at 6:23 AM#24

From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Worth separating that from cardiovascular outcomes, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Sep 24, 2025 at 8:23 AM
50 0JenMemphis, pat_auckland, Dr.GastroMayo and 47 others
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pete_RVA
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Sep 25, 2025 at 1:21 AM#25
Dr.NutriCornell said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Second this. Nothing to add that would improve it.

Last edited: Sep 25, 2025 at 6:21 AM
49 24Dr.LeslieOBGYN, MikeNYC_runner and 46 others
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