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ForumsCompounding & FormulationCompounded tirzepatide formulation challenges — looking for input Page 2

Compounded tirzepatide formulation challenges — looking for input

Dr.EndoIndy Tue, Jul 9, 2024 at 8:50 AM 43 replies 2,583 viewsPage 2 of 9
PeptideChemSF
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Jul 9, 2024 at 10:17 AM#6

One concrete data point for the thread. Two things anyone can check: a state licence number for a 503A, and an FDA outsourcing-facility registration for a 503B. Both are publicly searchable, and a pharmacy unwilling to give you either has answered the question.

Last edited: Jul 9, 2024 at 2:17 PM
19 22steve_okc, dave_SLC, FDA_TrackerJim and 16 others
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newstart_MO
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Jul 9, 2024 at 10:50 AM#7

One thing that is still open after pat_auckland’s answer:

Whether anyone has held 10mg long term rather than climbing, and what happened over the following year?

20 23LibrarianMeg, bri_stats, pete_manc_UK and 17 others
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SleepDoc_PDX
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Jul 9, 2024 at 11:23 AM#8
PeptideChemSF said:
Two things anyone can check: a state licence number for a 503A, and an FDA outsourcing-facility registration for a 503B.

Coming at PeptideChemSF’s question from a different direction. Resolution therefore closed the doors unevenly, and the asymmetry follows from the bulks lists. For 503B the shortage clause was the only route to these molecules, so that route shut completely. A 503A pharmacy can still argue a doorway via "component of an approved drug" — but only for the substance in the form present in the approved product, which is exactly where the base-versus-salt argument lives, and it does nothing about the copy restriction, which came back into force on resolution.

Last edited: Jul 9, 2024 at 2:23 PM
21 24carlos_SATX, sophie_paris, mel_PDX and 18 others
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Dr.EndoIndy
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Jul 9, 2024 at 11:56 AM#9

Reporting back.

I stayed at 10mg. Another six months, another 7kg, no new side effects, and my reading of the dose-response says the last two steps were never going to be worth what they cost me.

Last edited: Jul 9, 2024 at 2:56 PM
22 0DeniseRN_TPA, SandraNC_45, Dr.EndoIndy and 19 others
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nancy_portland
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Jul 9, 2024 at 2:35 PM#10
SleepDoc_PDX said:
Resolution therefore closed the doors unevenly, and the asymmetry follows from the bulks lists.

True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of people never reach the dose the headline number came from.

30 5claudia_zurich, nancy_portland, rick_sfbay and 27 others
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