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ForumsCompounding & FormulationNeedle gauge and dead space — need advice Page 3

Needle gauge and dead space — need advice

sarah_TO Wed, Jun 26, 2024 at 2:36 AM 14 replies 2,007 viewsPage 3 of 3
tommy_boulder
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Nov 2024
Boulder, CO
Jun 27, 2024 at 9:18 PM#11
KevinCompounds said:
Do it in two steps and it stops being confusing.

Saving this. It is the first explanation that did not require me to already understand it.

25 0paul_denver, TinaHashiRN, robert_kc and 22 others
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TrialNerd_Beth
Senior Member
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Jan 2024
Bethesda, MD
Jun 29, 2024 at 5:17 AM#12

Adding the clinical framing, because it changes how the question reads.

Comparison of compounded dosing arithmetic delivery formats I've tried:

FormatProsCons
Lyophilized vialLongest shelf life, lowest costRequires reconstitution
Pre-mixed vialReady to draw upShorter shelf life (28-45 days)
Pre-filled syringesMost convenientHigher cost, shorter shelf life
Sublingual dropsNo needlesLower bioavailability, less data

I use lyophilized vials for cost and stability. The reconstitution takes 30 seconds once you've done it a few times.

24 24PharmHunterJen, TomTeleRx, DoseLogDan and 21 others
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PharmD_Rodriguez
Senior Member
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Jan 2024
Miami, FL
Jun 30, 2024 at 1:16 PM#13
jim_asheville said:
For anyone reconstituting dosing arithmetic peptides: the water-to-powder ratio determines your concentration.

Just received my dosing arithmetic order — packaging review:

  • Outer box: plain brown, no medication identifiers (discreet) ✅
  • Inner insulation: Styrofoam with 4 gel ice packs ✅
  • Temperature: vials were cold to touch on arrival ✅
  • Labeling: lot number, BUD, compound name, concentration ✅
  • Included: COA, reconstitution instructions, dosing card ✅

This is what professional compounding pharmacy shipping looks like. If your order arrives without these basics, reconsider your vendor.

23 23robert_kc, dan_philly, MeganSA_TX and 20 others
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dave_SLC
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Aug 2024
Salt Lake City, UT
Jul 1, 2024 at 9:16 PM#14
sarah_TO said:
Concentration choice is a precision decision, not a preference.

Regarding dosing arithmetic multi-dose vial contamination prevention: after reconstituting, I wipe the vial stopper with a fresh alcohol swab before EVERY single draw. I also never touch the stopper with my fingers and use a new needle for each draw.

Even with bacteriostatic water preservative, contamination is cumulative. One sloppy draw can introduce bacteria that multiply over days. Aseptic technique isn't optional — it's essential for injectable medications.

22 22FranDenver, Dr.BariatricHTX, LindaRN_retired and 19 others
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Admin
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Online
Jul 3, 2024 at 5:17 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Carry on.

21 21PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 18 others
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