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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — my results so far

Lp(a) on GLP-1 agonists — my results so far

mike.trainer_LA Fri, May 16, 2025 at 9:18 AM 10 replies 1,436 viewsPage 1 of 2
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mike.trainer_LA
Senior Member
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Apr 2024
Los Angeles, CA
May 16, 2025 at 9:18 AM#1

Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been promised.

What would genuinely help is knowing whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.

Numbers rather than impressions, if you have them.

9 12Dr.AddMedPHL, newstart_MO, mia_MS2 and 6 others
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COA_Karl
Senior Member
2,123
8,901
Jan 2024
Pennsylvania
May 16, 2025 at 10:13 AM#2
mike.trainer_LA said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1568968Particle count (more precise than LDL-C)
Small dense LDL58%28%Atherogenic pattern
Remnant cholesterol3217Triglyceride-rich lipoproteins
oxLDL7346Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

10 13jim_asheville, matt_MKE, Dr.ReproEndo and 7 others
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Dr.PulmRoch
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Jun 2024
Rochester, MN
May 16, 2025 at 11:08 AM#3
COA_Karl said:
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1568 968 Particle…

Comprehensive lipid panel update relevant to the lipid panel:

MarkerBaseline6 Months12 MonthsReference
Total Cholesterol253208178<200
LDL15812398<100
HDL415265>40
Triglycerides273178108<150
LDL-P17331283983<1000

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

11 14AttorneyGrant, DebRD_ATL, KristenIndy and 8 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
May 16, 2025 at 12:03 PM#4
mike.trainer_LA said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.

Last edited: May 16, 2025 at 3:03 PM
12 15sophie_paris, mel_PDX, Dr.AddMedPHL and 9 others
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DebRD_ATL
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Feb 2024
Atlanta, GA
May 16, 2025 at 5:13 PM#5

Clinical perspective, offered as context rather than as advice.

Tracking labs for the lipid panel — here's the panel I get every 3 months and why:

  • CMP: glucose, electrolytes, kidney function, liver enzymes
  • Lipid panel: total cholesterol, LDL, HDL, triglycerides
  • A1C: 3-month glucose average
  • hsCRP: inflammatory marker
  • CBC: blood counts, anemia screening
  • B12, folate, iron: nutritional deficiency screening
  • TSH, free T4: thyroid monitoring
  • Lipase: pancreatic safety check

Total cost with insurance: about $38 copay. Without insurance, request cash-pay pricing from Quest/Labcorp — usually $163.

13 16HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 10 others
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