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Evidence-based GLP-1 & peptide discussion since 2023
ForumsClinical Trials & ResearchOrforglipron ATTAIN-4 — looking for input Page 2

Orforglipron ATTAIN-4 — looking for input

LabKate Sat, Feb 7, 2026 at 2:59 PM 14 replies 1,111 viewsPage 2 of 3
PurityPaulOR
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Feb 8, 2026 at 4:50 PM#6
pete_manc_UK said:
It helps to ask what evidence would change your mind before you look at any.

This is where I part company with the consensus forming above. Small molecule does not automatically mean cheap. Price is set by what the market will bear and by patent life, not by cost of goods, and I would not assume the savings reach patients.

20 23Dr.LeslieOBGYN, MikeNYC_runner and 17 others
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Dr.PeteFamMed
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Feb 9, 2026 at 3:08 AM#7

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Last edited: Feb 9, 2026 at 4:08 AM
21 24tommy_boulder, hyun_seoul, jim_asheville and 18 others
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PharmD_Rodriguez
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Feb 9, 2026 at 1:26 PM#8
PurityPaulOR said:
Small molecule does not automatically mean cheap.

Adding the part of the answer the thread has not reached. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

22 0robert_kc, dan_philly, MeganSA_TX and 19 others
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andrew_nyc
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Feb 9, 2026 at 11:45 PM#9

Following on from pete_RVA — and this may be the naive question:

Was that from a primary source or from a summary of one?

23 1julia.endo, JessicaM_2024, TomFromTexas and 20 others
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LabKate
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Feb 12, 2026 at 1:16 AM#10

OP back with an update, since a thread like this is useless without one.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.

Last edited: Feb 12, 2026 at 4:16 AM
3 1labquiet_amy, emily_PDX, Dr.SleepRoch
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