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ForumsCardiovascular OutcomesSOUL trial preliminary data — November 2025 Page 7

SOUL trial preliminary data — November 2025

JenMemphis Sun, Mar 16, 2025 at 2:50 AM 51 replies 2,130 viewsPage 7 of 11
BiostatsBrad
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Mar 29, 2025 at 8:34 AM#31
newstart_MO said:
The mechanism and the magnitude are separate questions.

There is a second half to this that has not been said yet. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

35 8LindaRN_retired, tommy_boulder, hyun_seoul and 32 others
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DanielChem_CHI
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Mar 30, 2025 at 4:15 AM#32

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

36 9Dr.DermMIA, fiona_VT, denise_HTX and 33 others
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jason_sac26
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Mar 30, 2025 at 11:55 PM#33

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

37 10stefan_berlin, Dr.EM_Chicago, pete_RVA and 34 others
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dave_SLC
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Mar 31, 2025 at 7:35 PM#34
DanielChem_CHI said:
Practical: whatever you change, write down the date and the reason.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Last edited: Mar 31, 2025 at 11:35 PM
38 11FranDenver, Dr.BariatricHTX, LindaRN_retired and 35 others
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Dr.CardioMD
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Apr 1, 2025 at 3:14 PM#35
DanielChem_CHI said:
Practical: whatever you change, write down the date and the reason.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: Apr 1, 2025 at 9:14 PM
39 12josh_phd_bmore, roxy_nash, tony_orlando and 36 others
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