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ForumsClinical Trials & ResearchBimagrumab + semaglutide — my results so far Page 3

Bimagrumab + semaglutide — my results so far

MaxMetOK Fri, Jan 9, 2026 at 3:38 PM 32 replies 1,200 viewsPage 3 of 7
Dr.BariatricHTX
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Jan 10, 2026 at 2:46 PM#11
sarah_TO said:
It helps to ask what evidence would change your mind before you look at any.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

I would rather be corrected than agreed with, if it comes to it.

37 10CarlaRPh_TPA, steph_laguna, fiona_glasgow and 34 others
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Dr.NephBHM_UK
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Jan 10, 2026 at 5:42 PM#12
rick_sfbay said:
Steady state is the thing most people miss.

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

Last edited: Jan 10, 2026 at 11:42 PM
38 11EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 35 others
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DerekSJ_a1c
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Jan 10, 2026 at 8:38 PM#13
sarah_TO said:
It helps to ask what evidence would change your mind before you look at any.

This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Jan 11, 2026 at 1:38 AM
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LabKate
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Jan 10, 2026 at 11:34 PM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

I would rather be corrected than agreed with, if it comes to it.

40 13emily_PDX, Dr.SleepRoch, laura_annarbor and 37 others
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mike_mod
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Jan 11, 2026 at 2:29 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

41 14PurityPaulOR, MaxMetOK, MounjBrad and 38 others
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