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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — anyone have experience?

Lp(a) on GLP-1 agonists — anyone have experience?

CryptoCarl Sun, Aug 4, 2024 at 1:09 PM 9 replies 1,886 viewsPage 1 of 2
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CryptoCarl
Member
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May 2024
Arizona
Aug 4, 2024 at 1:09 PM#1

Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been promised.

What I am trying to establish is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.

Practical detail welcome, however dull — the duller the better.

32 2CryptoCarl, MariaRD, AussieAnna and 29 others
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Dr.RenalNash
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Mar 2024
Nashville, TN
Aug 4, 2024 at 1:20 PM#2
CryptoCarl said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

CategoryMarkerBeforeAfter 11moChange
MetabolicA1C7.2%5.7%⬇️ 1.4%
MetabolicFasting Glucose11688⬇️ 36
LipidsLDL159103⬇️ 51
LipidsTriglycerides231106⬇️ 101
InflammationhsCRP8.50.9⬇️ 6.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

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TrialNerd_Beth
Senior Member
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Jan 2024
Bethesda, MD
Aug 4, 2024 at 1:31 PM#3
Dr.RenalNash said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Tracking labs for the lipid panel — here's the panel I get every 3 months and why:

  • CMP: glucose, electrolytes, kidney function, liver enzymes
  • Lipid panel: total cholesterol, LDL, HDL, triglycerides
  • A1C: 3-month glucose average
  • hsCRP: inflammatory marker
  • CBC: blood counts, anemia screening
  • B12, folate, iron: nutritional deficiency screening
  • TSH, free T4: thyroid monitoring
  • Lipase: pancreatic safety check

Total cost with insurance: about $38 copay. Without insurance, request cash-pay pricing from Quest/Labcorp — usually $173.

Last edited: Aug 4, 2024 at 5:31 PM
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tammy_FL
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Nov 2024
Tampa, FL
Aug 4, 2024 at 1:42 PM#4
CryptoCarl said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Can confirm. Same sequence, different timescale. Posting only so the count is not one.

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Dr.LipidDallas
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Dec 2023
Dallas, TX
Aug 4, 2024 at 2:40 PM#5

Adding the clinical framing, because it changes how the question reads.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.2% to 8.7% over 11 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

Last edited: Aug 4, 2024 at 4:40 PM
28 23Dr.PulmRoch, maya_sedona, stefan_berlin and 25 others
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