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ForumsCardiovascular OutcomesApoB reduction on tirzepatide — looking for input Page 3

ApoB reduction on tirzepatide — looking for input

TomTeleRx Tue, Jul 9, 2024 at 9:38 AM 34 replies 2,140 viewsPage 3 of 7
SleepFixSam
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Jul 10, 2024 at 12:25 PM#11
VendorMark said:
The GIP arm is doing real work rather than padding the label.

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

23 21pete_nash, hank_denver, carlos_SATX and 20 others
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sean_dublin
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Jul 10, 2024 at 3:07 PM#12

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Happy to go further on any of that.

24 22sean_dublin, hannah_MT, Dr.SportsMedIN and 21 others
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PharmacoVig_BOS
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Jul 10, 2024 at 5:49 PM#13
Dr.EM_Chicago said:
ApoB is the more informative number and it is cheap.

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

Last edited: Jul 10, 2024 at 8:49 PM
25 23DataDave, Dr.GutHealth, amsterdam_pete and 22 others
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Dr.NateNeph
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Jul 10, 2024 at 8:31 PM#14

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Jul 10, 2024 at 10:31 PM
26 24B12Beth, RickReta_CO, PharmHunterJen and 23 others
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Admin
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Jul 10, 2024 at 11:13 PM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. No action needed from anybody.

27 0PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 24 others
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