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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesSOUL trial preliminary data — what worked for you? Page 3

SOUL trial preliminary data — what worked for you?

Dr.KarenChen Thu, May 16, 2024 at 2:46 PM 13 replies 2,080 viewsPage 3 of 3
FDA_TrackerJim
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May 21, 2024 at 4:05 AM#11
VendorMark said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

I would rather be corrected than agreed with, if it comes to it.

11 9Dr.Martinez, mike_mod, SarahChen_PharmD and 8 others
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SteveThurs
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May 23, 2024 at 9:31 PM#12
carl_compliance said:
Dr.ReproEndo said: ...regarding the trial evidence...

Saving this. It is the first explanation that did not require me to already understand it.

12 10PurityPaulOR, MaxMetOK, MounjBrad and 9 others
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RickReta_CO
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May 26, 2024 at 2:58 PM#13
VendorMark said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

13 11hyun_seoul, jim_asheville, matt_MKE and 10 others
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SleepDoc_PDX
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May 29, 2024 at 8:27 AM#14

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Last edited: May 29, 2024 at 11:27 AM
14 12sophie_paris, mel_PDX, Dr.AddMedPHL and 11 others
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Admin
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Jun 1, 2024 at 1:57 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

Last edited: Jun 1, 2024 at 5:57 AM
15 13PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 12 others
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