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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersLipid panel improvements mega-thread — November 2025 Page 2

Lipid panel improvements mega-thread — November 2025

MikeFit_NJ Tue, Dec 2, 2025 at 1:28 AM 10 replies 1,176 viewsPage 2 of 2
pete_manc_UK
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Dec 2, 2025 at 8:52 AM#6
RetaRick_CA said:
Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c…

Pushing back on RetaRick_CA here. I would drop the "get everything" instinct further than this thread does. Every extra test is another chance at a false positive, and incidental findings have their own cost in scans, biopsies and worry.

Ask again with the specifics and you will get a better answer than this one.

50 20TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 47 others
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dave_SLC
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Dec 2, 2025 at 11:46 AM#7
MikeFit_NJ said:
My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

Shot day Wednesday report relevant to baseline bloodwork:

Week 13. Currently on 0.5mg. Down 39 lbs from starting weight of 251 lbs.

This week's observations: Mild fatigue day 1-2 post-injection, then fine.

Labs due next week — looking forward to seeing the metabolic panel. I'll post results in the Lab Results section when they come in.

Last edited: Dec 2, 2025 at 3:46 PM
49 19NicoleRaleigh, james_edin, FranDenver and 46 others
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LibrarianMeg
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Dec 2, 2025 at 2:41 PM#8
pete_manc_UK said:
I would drop the "get everything" instinct further than this thread does.

There is a second half to this that has not been said yet. ApoB is the more informative number and it is cheap. LDL-C estimates cholesterol mass in atherogenic particles; ApoB counts the particles, and it is particle count that tracks risk — which is why the two can disagree and why the disagreement is the clinically interesting case. Triglycerides fall substantially with weight loss and improved insulin sensitivity, HDL moves modestly, and LDL-C often barely moves at all, which surprises people who expected everything to improve together.

48 18julia.endo, JessicaM_2024, TomFromTexas and 45 others
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Dr.LeslieOBGYN
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Dec 2, 2025 at 5:36 PM#9

Following on from JenPlateau — and this may be the naive question:

How often to repeat it, because quarterly seems to be the convention and I cannot find the reasoning?

47 17NicoleRaleigh, james_edin, FranDenver and 44 others
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MikeFit_NJ
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Dec 3, 2025 at 7:34 AM#10

Closing the loop on my own question.

Took the whole panel in rather than the one flagged line, and the conversation lasted two minutes instead of generating three more tests.

Last edited: Dec 3, 2025 at 10:34 AM
21 19Dr.EndoIndy, tom_AK, josh_phd_bmore and 18 others
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