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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersSHBG changes during weight loss on GLP-1 — my results so far Page 6

SHBG changes during weight loss on GLP-1 — my results so far

tampaLisa73 Thu, Sep 18, 2025 at 7:38 AM 45 replies 1,803 viewsPage 6 of 9
sophie_paris
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Nov 21, 2025 at 6:06 PM#26
Dr.RenalNash said:
It helps to ask what evidence would change your mind before you look at any.

This is my experience too, for whatever a second data point is worth. The detail I would add is minor and it is already implied above.

41 14SallyK_inj, CryptoCarl, MariaRD and 38 others
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JennaRN
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Nov 30, 2025 at 6:58 AM#27
Dr.RenalNash said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

42 15PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 39 others
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Dr.GutHealth
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Dec 8, 2025 at 7:45 PM#28

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: Dec 9, 2025 at 12:45 AM
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MikeFit_NJ
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Dec 17, 2025 at 8:28 AM#29

Following on from Dr.RenalNash — and this may be the naive question:

How long did you give it before you decided it was working?

Last edited: Dec 17, 2025 at 11:28 AM
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tampaLisa73
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Dec 25, 2025 at 9:06 PM#30

OP back with an update, since a thread like this is useless without one.

Resolved, and the thing that resolved it was the least interesting suggestion in the thread. Writing that down for the next person who wants the interesting answer.

16 14TomFromTexas, mike.trainer_LA, sarah_nash92 and 13 others
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