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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsRetatrutide cholesterol effects — looking for input Page 3

Retatrutide cholesterol effects — looking for input

jennifer_SEA Mon, Dec 22, 2025 at 4:43 PM 15 replies 1,091 viewsPage 3 of 3
BethLabQueen
Senior Member
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Virginia
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Dec 27, 2025 at 2:15 PM#11
LibrarianMeg said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 3.7% to 8.7% over 8 months.

Tracking labs for the lipid panel — here's the panel I get every 3 months and why:

  • CMP: glucose, electrolytes, kidney function, liver enzymes
  • Lipid panel: total cholesterol, LDL, HDL, triglycerides
  • A1C: 3-month glucose average
  • hsCRP: inflammatory marker
  • CBC: blood counts, anemia screening
  • B12, folate, iron: nutritional deficiency screening
  • TSH, free T4: thyroid monitoring
  • Lipase: pancreatic safety check

Total cost with insurance: about $40 copay. Without insurance, request cash-pay pricing from Quest/Labcorp — usually $185.

33 6maya_sedona, stefan_berlin, Dr.EM_Chicago and 30 others
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mel_PDX
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Dec 2024
Portland, OR
Dec 28, 2025 at 6:29 PM#12
LabKate said:
Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

34 7Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 31 others
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TomTeleRx
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Feb 2025
Delaware
Dec 29, 2025 at 10:42 PM#13
LibrarianMeg said:
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 3.7% to 8.7% over 8 months.

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

35 8LibrarianMeg, bri_stats, pete_manc_UK and 32 others
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josh_phd_bmore
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Baltimore, MD
Dec 31, 2025 at 2:54 AM#14
jennifer_SEA said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1635935Particle count (more precise than LDL-C)
Small dense LDL55%31%Atherogenic pattern
Remnant cholesterol3514Triglyceride-rich lipoproteins
oxLDL8043Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

36 9KarenAZ_mom, zoe_NC, Dr.ObesityLA and 33 others
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mike_mod
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Jan 1, 2026 at 7:06 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

37 10PurityPaulOR, MaxMetOK, MounjBrad and 34 others
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