Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.
The narrow version of the question is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.
I have searched first, so if this is covered somewhere point me at it and I will read it.
This one has a reasonably settled answer, so here it is. The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study. A curve that has not flattened is a real finding, but it also means the true plateau is unknown, and phase 2 populations are small and selected.
Dr.GutHealth said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale. Triple agonism means three receptor systems generating adverse events, and the dropout column is the one I would read first when the larger trials report.
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Browse GL Biochemjennifer_SEA said:Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.
Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.
Clinical perspective, offered as context rather than as advice.
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:
| Category | Marker | Before | After 13mo | Change |
|---|---|---|---|---|
| Metabolic | A1C | 7.6% | 5.5% | ⬇️ 1.8% |
| Metabolic | Fasting Glucose | 128 | 90 | ⬇️ 33 |
| Lipids | LDL | 171 | 100 | ⬇️ 53 |
| Lipids | Triglycerides | 273 | 118 | ⬇️ 103 |
| Inflammation | hsCRP | 6.5 | 1.1 | ⬇️ 6.0 |
Every single metabolic marker improved. This is why I'm a believer in this therapy.