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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersLiver enzymes trending down on GLP-1 — anyone have experience? Page 3

Liver enzymes trending down on GLP-1 — anyone have experience?

DeniseRN_TPA Tue, Apr 15, 2025 at 4:48 PM 23 replies 1,941 viewsPage 3 of 5
Dr.EM_Chicago
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Apr 18, 2025 at 12:11 AM#11
Dr.ObesityMed said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

39 12jim_asheville, matt_MKE, Dr.ReproEndo and 36 others
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JenPlateau
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Apr 18, 2025 at 5:35 AM#12

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Last edited: Apr 18, 2025 at 11:35 AM
40 13TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 37 others
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julia.endo
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Apr 18, 2025 at 10:59 AM#13
PharmD_Rodriguez said:
NASH/MAFLD therapeutic landscape and liver and MASH: GLP-1 agonists are emerging as potential first-line NASH therapy.

This is where I part company with the consensus forming above. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

41 14hans_munich, jason_sac26, chris_chi24 and 38 others
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DoseLogDan
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Feb 2025
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Apr 18, 2025 at 4:23 PM#14

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

42 15sophie_paris, mel_PDX, Dr.AddMedPHL and 39 others
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Admin
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Apr 18, 2025 at 9:47 PM#15

Moderator note: a couple of off-topic posts removed. Carry on.

43 16PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 40 others
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