This one has a reasonably settled answer, so here it is. ApoB is the more informative number and it is cheap. LDL-C estimates cholesterol mass in atherogenic particles; ApoB counts the particles, and it is particle count that tracks risk — which is why the two can disagree and why the disagreement is the clinically interesting case. Triglycerides fall substantially with weight loss and improved insulin sensitivity, HDL moves modestly, and LDL-C often barely moves at all, which surprises people who expected everything to improve together.

labquiet_amy said:

ApoB is the more informative number and it is cheap.

Agreed, and hsCRP is worth reading alongside them. The inflammatory-marker fall is often the most striking change on a panel and it is consistent with the cardiovascular outcome data.

Dr.ObesityMed said:

Living somewhere the domestic route does not exist, which makes most of the advice on this board inapplicable to me.

Adding a me-too, because a thread of one person's experience is not much use.

From the other side of the consultation, briefly.

My experience ordering cross-border ordering internationally: I've ordered from an Australian compounder. Customs can be hit or miss.

Shipping time: 5-10 days
Customs clearance: was seized once, reshipped free
Quality: Janoshik tested at 97.0% purity

International ordering adds complexity but can save 60-80% compared to US prices. Research your country's import laws first.