Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
One thing that is still open after Dr.PathRoch’s answer:
What did you change at the same time, and can you separate the two now?
josh_phd_bmore said:Practical: whatever you change, write down the date and the reason.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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Browse GL Biochemjosh_phd_bmore said:Practical: whatever you change, write down the date and the reason.
Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.
Found this through search years later and it is still the best discussion of the question, so adding one thing. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.