TrialTracker_MD said:Start from the measurement rather than the conclusion.
That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.
Happy to go further on any of that.
mel_PDX said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.
TrialTracker_MD said:Start from the measurement rather than the conclusion.
I read this differently from TrialTracker_MD, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
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Browse GL BiochemAdding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.