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ForumsLab Results & BiomarkersSHBG changes during weight loss on GLP-1 — need advice Page 4

SHBG changes during weight loss on GLP-1 — need advice

TirzTom Thu, Feb 8, 2024 at 2:05 AM 53 replies 3,010 viewsPage 4 of 11
NurseAsh_DET
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Feb 11, 2024 at 3:58 AM#16

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

16 14FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 13 others
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tom_AK
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Feb 11, 2024 at 10:18 AM#17
PharmacoVig_BOS said:
Practical: whatever you change, write down the date and the reason.

Agreeing with PharmacoVig_BOS, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Feb 11, 2024 at 2:18 PM
17 15VanRx_Mike, steve_okc, dave_SLC and 14 others
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matt_MKE
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Feb 11, 2024 at 4:38 PM#18
PharmacoVig_BOS said:
Practical: whatever you change, write down the date and the reason.

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

18 16GraceAZ_72, carl_compliance, DanielChem_CHI and 15 others
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Dr.SportsMedIN
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Feb 11, 2024 at 10:58 PM#19

From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

19 17Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 16 others
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Admin
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Feb 12, 2024 at 5:18 AM#20

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

Last edited: Feb 12, 2024 at 9:18 AM
41 14PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 38 others
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