sophie_paris said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Dr.LeslieOBGYN said:

The mechanism is more central than most summaries suggest.

This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.

sophie_paris said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.