🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Semaglutide and lean mass: DEXA scan longitudinal data

Semaglutide and lean mass: DEXA scan longitudinal data

MikeFit_NJ Thu, May 28, 2026 at 8:31 PM 28 replies 916 viewsPage 1 of 6
MikeFit_NJ
Senior Member
1,567
6,543
Apr 2024
New Jersey
May 28, 2026 at 8:31 PM#1

Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean. I want to know whether that ratio is bad, normal, or simply what happens.

The question I want answered is what fraction of loss being lean mass is actually normal, because the numbers quoted here range from 10% to 40% and cannot all be right.

Numbers rather than impressions, if you have them.

37 7LeilaHI, marcus_mpls, DeniseRN_TPA and 34 others
Reply Quote Save Share Report
PeptideChemSF
Senior Member
1,890
9,012
Jan 2024
San Francisco, CA
May 28, 2026 at 8:32 PM#2

Short answer first, then the reasoning. The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0 g/kg of reference body weight, and not making the deficit larger than the training can support. Cardio does not protect lean mass and in a deep deficit competes with recovery.

36 6dave_SLC, FDA_TrackerJim, ricardo_MIA and 33 others
Reply Quote Save Share Report
mike_nyc
VIP Member
5,678
21,345
Nov 2023
New York
Online
May 28, 2026 at 8:32 PM#3
PeptideChemSF said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution. Hydration status moves the lean compartment by a kilogram or more between scans, so any comparison of scans done at different times of day or different hydration states is noise.

Last edited: May 29, 2026 at 12:32 AM
35 5Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 32 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
marcus_mpls
Member
234
1,123
Nov 2024
Minneapolis, MN
May 28, 2026 at 8:33 PM#4
MikeFit_NJ said:
Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean.

Can confirm the pattern MikeFit_NJ describes. The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate protein. Both numbers need a caveat that matters: "lean mass" on a DEXA is not muscle. It includes water, glycogen and the lean fraction of organs, and glycogen alone carries about three grams of water per gram. A large early lean drop is mostly the glycogen and water going, which is why the first scan flatters and the second is the honest one.

Correct me if the detail matters more than I have assumed.

34 4Dr.PathRoch, mona_PHX, andrew_nyc and 31 others
Reply Quote Save Share Report
Dr.NephBHM_UK
Member
456
2,123
Jun 2024
Birmingham, UK
May 28, 2026 at 8:35 PM#5

From the other side of the consultation, briefly.

DEXA scan update relevant to lean mass:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass259 lbs239 lbs216 lbs
Fat mass119 lbs79 lbs51 lbs
Lean mass157 lbs150 lbs153 lbs
Body fat %44%30%25%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.

33 3PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 30 others
Reply Quote Save Share Report
1236

Similar Threads

STEP 1-5 trials comprehensive summary — efficacy endpoints compiled12 replies
Oral semaglutide 50mg Phase 3 — OASIS program results16 replies
Semaglutide pharmacokinetics — half-life, Tmax, steady state modeling10 replies
Compounded semaglutide stability data — temperature and light sensitivity16 replies
0.25mg → 2.4mg titration: optimal schedule based on clinical data6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register