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ForumsSemaglutide (Ozempic / Wegovy)A1C reduction on semaglutide: SUSTAIN program meta-analysis Page 4

A1C reduction on semaglutide: SUSTAIN program meta-analysis

A1cHero_PHX Tue, May 19, 2026 at 4:00 AM 22 replies 520 viewsPage 4 of 5
Dr.MetabolicMD
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May 23, 2026 at 2:19 PM#16
MASHdoc_SA said:
A1cHero_PHX said: ...but the FDA says semaglutide...

Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.

I would rather be corrected than agreed with, if it comes to it.

Last edited: May 23, 2026 at 4:19 PM
21 19SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 18 others
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paul_denver
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May 24, 2026 at 7:16 AM#17
Dr.PulmRoch said:
A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator.

Thank you for spelling out the reasoning rather than just the conclusion.

Last edited: May 24, 2026 at 1:16 PM
22 20jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 19 others
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SleepDoc_PDX
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May 25, 2026 at 12:13 AM#18

Clinical perspective, offered as context rather than as advice. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

23 21carlos_SATX, sophie_paris, mel_PDX and 20 others
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BariatricNurseD
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May 25, 2026 at 5:10 PM#19
SleepDoc_PDX said:
Worth answering the question that was asked rather than the one behind it.

Can confirm. Same sequence, different timescale.

24 22tom_AK, josh_phd_bmore, roxy_nash and 21 others
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Admin
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May 26, 2026 at 10:07 AM#20

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Thread quality here is what the rules are for. Keep it up.

Last edited: May 26, 2026 at 2:07 PM
46 19PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 43 others
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