🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionResistance training prevents 73% lean mass loss on semaglutide — RCT review Page 2

Resistance training prevents 73% lean mass loss on semaglutide — RCT review

MikeFit_NJ Mon, Jun 8, 2026 at 6:43 AM 11 replies 220 viewsPage 2 of 3
BethLabQueen
Senior Member
1,234
5,678
May 2024
Virginia
Online
Jun 8, 2026 at 7:46 AM#6
I know I benefited from "newbie gains" since I hadn't lifted seriously in ~20 years.

This is honest and important context. The lean mass gain you're seeing is partly muscle memory (satellite cell-mediated re-growth of previously trained fibers) and partly true newbie gains. A trained individual in the same situation would not see 5 lbs of lean gain during a 40-lb weight loss.

But here's the thing: most people starting GLP-1 therapy AREN'T trained. So your results ARE representative of what an untrained or detrained person can achieve if they commit to resistance training from day one. That's the message worth amplifying.

Last edited: Jun 8, 2026 at 8:46 AM
7 2maya_sedona, stefan_berlin, Dr.EM_Chicago and 4 others
Reply Quote Save Share Report
jason_paloalto
Member
212
890
Nov 2024
Palo Alto, CA
Jun 8, 2026 at 8:11 AM#7

Those deadlift numbers at 55... respect. I'm 34 and can barely pull 200. Time to stop making excuses.

6 1Dr.PathRoch, mona_PHX, andrew_nyc and 3 others
Reply Quote Save Share Report
DeniseRN_TPA
Member
345
1,567
Aug 2024
Tampa, FL
Jun 8, 2026 at 8:35 AM#8

Ha, thanks. And honestly, the best part isn't the numbers on the bar — it's how I FEEL. I move differently. I stand up straighter. My lower back doesn't ache anymore. I carried all the groceries in one trip last week and my wife looked at me like I was showing off (I was). At 55, I feel physically better than I did at 40. That's not an exaggeration.

5 0tommy_boulder, hyun_seoul, jim_asheville and 2 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem

Similar Threads

DEXA scan longitudinal data — 12 months on GLP-1 + lifting18 replies
Zone 2 cardio + GLP-1: synergistic metabolic benefits — evidence18 replies
Creatine kinase elevations on GLP-1 — exercise-induced or concerning?14 replies
Body recomposition protocol: GLP-1 + progressive overload + high protein8 replies
Walking 10,000 steps/day impact on GLP-1 weight loss — pedometer study6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register