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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — exercise-induced or concerning? Page 3

Creatine kinase elevations on GLP-1 — exercise-induced or concerning?

Dr.Martinez Sun, Jun 7, 2026 at 4:38 PM 14 replies 204 viewsPage 3 of 3
sarah_TO
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Jun 8, 2026 at 12:36 PM#11
hans_munich said:
There is also a quality change that the scan cannot see.

Thank you for spelling out the reasoning rather than just the conclusion. Sending this to two other people who asked me the same thing last week.

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Dr.CardioMD
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Jun 8, 2026 at 2:50 PM#12

Adding the clinical framing, because it changes how the question reads.

Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Lumbar spine T-score: -0.8 → -0.7 (stable to slightly improved)
Femoral neck T-score: -0.12 → -0.8 (stable)

No significant bone loss despite 65 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.

Last edited: Jun 8, 2026 at 8:50 PM
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pete_manc_UK
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Jun 8, 2026 at 5:03 PM#13
Dr.BariatricHTX said:
Training does two things here and only one of them is on the scale.

DEXA scan update relevant to lean mass:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass248 lbs218 lbs195 lbs
Fat mass98 lbs68 lbs45 lbs
Lean mass151 lbs147 lbs152 lbs
Body fat %41%33%24%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.

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TirzTom
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Jun 8, 2026 at 7:16 PM#14
Dr.Martinez said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

My endo's protocol for lean mass plateau: if weight loss stalls for 6+ weeks at current dose, we go through this checklist before titrating up:

  1. Food diary review — is intake creeping up?
  2. Protein check — minimum 100g/day
  3. Activity audit — steps + resistance training
  4. Sleep quality — poor sleep kills GLP-1 efficacy
  5. Stress/cortisol management

Only after addressing all of these do we increase the dose. Often fixing one lifestyle factor restarts progress without needing more medication.

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Admin
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Jun 8, 2026 at 9:29 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

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