Dr.PathRoch said:

The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate…

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

From the other side of the consultation, briefly.

Pet owner bonus of training: my dog is also losing weight because we're walking 2-3x more than before. His vet is thrilled. 🐕

We went from a 5-minute shuffle around the block to 30-minute walks through the neighborhood. He's more energetic, I'm more energetic, and we're both healthier.

Get a dog. Or borrow one. Walking a dog is the best low-impact exercise motivation that exists. They never let you skip a walk. 🐾

LibrarianMeg said:

There is also a quality change that the scan cannot see.

Exercise-induced nausea amplification with training: I learned the hard way that intense exercise within 36 hours of injection can make nausea much worse. The combination of delayed gastric emptying + exercise-induced blood flow redistribution is rough on the GI system.

My workaround: inject Friday evening, do low-intensity activity Saturday, and save my intense workouts for Tuesday-Thursday when the GI effects have subsided. Timing your training around your injection schedule is a real optimization strategy.

mike.trainer_LA said:

Training does two things here and only one of them is on the scale.

Exercise transformation with training: went from barely able to walk a block to completing a 10K last weekend.

My fitness journey alongside GLP-1 therapy:

• Month 1-2: Walking 15 min/day
• Month 3-4: Walking 30-45 min, started bodyweight exercises
• Month 5-6: Joined a gym, started resistance training
• Month 7+: Running, lifting heavy, swimming for fun

The weight loss made movement possible. The movement made more weight loss possible. Virtuous cycle in action.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.