Taking the question as asked, rather than the general version of it. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.

labquiet_amy said:

The mechanism that matters here is not stomach emptying, it is central.

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

RunnerRach said:

Training four times a week throughout and the scale has barely acknowledged it, which is demoralising in a way I did not expect.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

From the other side of the consultation, briefly.

Pet owner bonus of training: my dog is also losing weight because we're walking 2-3x more than before. His vet is thrilled. 🐕

We went from a 15-minute shuffle around the block to 60-minute walks through the neighborhood. He's more energetic, I'm more energetic, and we're both healthier.

Get a dog. Or borrow one. Walking a dog is the best low-impact exercise motivation that exists. They never let you skip a walk. 🐾