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ForumsMASH / Liver DiseaseMy liver enzyme journey — ALT from 98 to 19 on semaglutide Page 5

My liver enzyme journey — ALT from 98 to 19 on semaglutide

DerekSJ_a1c Wed, May 27, 2026 at 9:10 AM 29 replies 552 viewsPage 5 of 6
wanda_boise
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May 29, 2026 at 10:52 PM#21
TrialTracker_MD said:
The mechanism that matters here is not stomach emptying, it is central.

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

Last edited: May 30, 2026 at 3:52 AM
46 19DanielChem_CHI, marco_milano, pam_columbus and 43 others
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PeptideChemSF
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May 30, 2026 at 11:01 PM#22
TrialTracker_MD said:
The mechanism that matters here is not stomach emptying, it is central.

Genuinely useful, thank you. I had the facts and not the framework.

47 20dave_SLC, FDA_TrackerJim, ricardo_MIA and 44 others
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pat_auckland
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May 31, 2026 at 11:08 PM#23

Clinical perspective, offered as context rather than as advice. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

48 21LarryQC_SD, wanda_boise, NurseAsh_DET and 45 others
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tane_welly
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Jun 1, 2026 at 11:16 PM#24
pat_auckland said:
Worth answering the question that was asked rather than the one behind it.

Mine went the same way, slower. I had assumed I was the exception until I read this.

Last edited: Jun 2, 2026 at 2:16 AM
49 22marco_milano, pam_columbus, nick_SD_fit and 46 others
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ChrisMacros
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Jun 2, 2026 at 11:22 PM#25
pat_auckland said:
Worth answering the question that was asked rather than the one behind it.

There is a second half to this that has not been said yet. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Jun 3, 2026 at 2:22 AM
50 23bri_stats, pete_manc_UK, anna.melb_AU and 47 others
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