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ForumsSemaglutide (Ozempic / Wegovy)0.25mg → 2.4mg titration: optimal schedule based on clinical data — looking for input Page 7

0.25mg → 2.4mg titration: optimal schedule based on clinical data — looking for input

anders_CPH Mon, Feb 2, 2026 at 2:28 AM 33 replies 1,047 viewsPage 7 of 7
TirzTom
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Mar 31, 2026 at 1:45 AM#31

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

22 20josh_phd_bmore, roxy_nash, tony_orlando and 19 others
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jason_paloalto
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Apr 4, 2026 at 11:19 AM#32

Following on from Dr.GastroMayo — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

Last edited: Apr 4, 2026 at 4:19 PM
23 21Dr.PathRoch, mona_PHX, andrew_nyc and 20 others
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Dr.MetabolicMD
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Apr 8, 2026 at 8:51 PM#33
TirzTom said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Pushing back on TirzTom here. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

24 22HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 21 others
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SkepticalSean
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Apr 13, 2026 at 6:20 AM#34
TirzTom said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Happy to go further on any of that.

25 23tammy_FL, Dr.LipidDallas, alex_tucson and 22 others
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paige_pharma
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Apr 17, 2026 at 3:47 PM#35
TirzTom said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

Last edited: Apr 17, 2026 at 4:47 PM
26 24lucas_SP_BR, lisa_labSD, adam_van and 23 others
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