Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

One thing that is still open after Dr.PulmRoch’s answer:

How long did you give it before you decided it was working?

dan_philly said:

The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

I read this differently from dan_philly, on substance rather than tone. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.

That is the short version; the long version is somebody else's post.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.