Dr.ReproEndo said:

Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…

Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):

Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.

Dr.AddMedPHL said:

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.

This answered a question I did not know how to ask.

Dr.ReproEndo said:

Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…

OMG yes. lean mass + resistance training is the combo. Can confirm.

AussieAnna said:

I lifted three times a week throughout and still lost lean mass.

Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Lumbar spine T-score: -0.10 → -0.9 (stable to slightly improved)
Femoral neck T-score: -0.14 → -0.10 (stable)

No significant bone loss despite 67 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.