Dr.MetabolicMD said:

The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

MASHdoc_SA said:

The mechanism that matters here is not stomach emptying, it is central.

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

Dr.MetabolicMD said:

The distinction that resolves most of these threads is between what is true on average and what is true for one person.

I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

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