Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
Dr.DermMIA said:If two explanations both fit, the useful question is which one predicts something the other does not.
Can confirm. Same sequence, different timescale.
Dr.DermMIA said:If two explanations both fit, the useful question is which one predicts something the other does not.
Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
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One thing that is still open after Dr.DermMIA’s answer:
What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?