anders_CPH said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.
anders_CPH said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
Coming at anders_CPH’s question from a different direction. SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1. Different trials, different populations, so the comparison is indicative rather than decisive — but SURPASS-2 was a genuine head-to-head and it pointed the same way.
I would rather be corrected than agreed with, if it comes to it.
Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
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View ResultsFollowing on from anders_CPH — and this may be the naive question:
Whether anyone has held 10mg long term rather than climbing, and what happened over the following year?
raj_cambridge said:Say what you would expect to see if you were wrong, before you look.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.
Ask again with the specifics and you will get a better answer than this one.