PeptideSynthNJ said:

Distribution matters less than total but it is not nothing.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

Following on from PharmD_Rodriguez — and this may be the naive question:

How people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness?

lisa_labSD said:

DEXA scan update relevant to protein intake: Scanned at months 0, 6, and 12.

Adding the part of the answer the thread has not reached. The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously. On the positive side: reduced anxiety around food, better self-image, more confidence. On the difficult side: grief for the years lost, identity disruption, relationships built around eating, and the loss of food as a coping mechanism with nothing put in its place. Rarer but real: anhedonia and emotional flatness. Regulators have started asking for validated patient-reported outcomes in this class; the existing data gap is not evidence of absence.

OP back with an update, since a thread like this is useless without one.

Front-loading was the answer. Same total intake, same drug, but two thirds of the protein before midday and I am hitting the target most days now.

paige_pharma said:

The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

Correct me if the detail matters more than I have assumed.