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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — anyone have experience? Page 5

Diarrhea vs constipation on GLP-1 — anyone have experience?

HPLC_Greg Sun, Jan 4, 2026 at 3:28 AM 21 replies 1,190 viewsPage 5 of 5
Dr.PathRoch
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Rochester, MN
Feb 2, 2026 at 9:47 PM#21

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Feb 3, 2026 at 3:47 AM
37 10MikeFit_NJ, InsuranceTom, WendyG_ATL and 34 others
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MikeFit_NJ
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Apr 2024
New Jersey
Feb 14, 2026 at 2:27 PM#22

One thing that is still open after LibrarianMeg’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

38 11marcus_mpls, DeniseRN_TPA, SandraNC_45 and 35 others
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lori_vegas
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Las Vegas, NV
Feb 26, 2026 at 7:00 AM#23
Dr.PathRoch said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Last edited: Feb 26, 2026 at 9:00 AM
39 12oliver_london, tane_welly, Dr.PathRoch and 36 others
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carl_compliance
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Nov 2024
Raleigh, NC
Mar 9, 2026 at 11:27 PM#24
Dr.PathRoch said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Last edited: Mar 10, 2026 at 2:27 AM
40 13FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 37 others
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ben_calgary
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Oct 2024
Calgary, CA
Mar 21, 2026 at 3:47 PM#25
Dr.PathRoch said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Saving this. It is the first explanation that did not require me to already understand it.

Last edited: Mar 21, 2026 at 9:47 PM
41 14NauseaFreeNow, SteveThurs, B12Beth and 38 others
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