HPLC_Greg said:Worth knowing that the injection site changes very little.
No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.
HPLC_Greg said:Worth knowing that the injection site changes very little.
Saving this. It is the first explanation that did not require me to already understand it. Sending this to two other people who asked me the same thing last week.
Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
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Shop Reference StandardsKevinCompounds said:The version of this that has an answer is narrower than the version being asked.
Mine went the same way, slower. Nothing to add that would improve it.
KevinCompounds said:The version of this that has an answer is narrower than the version being asked.
Adding the part of the answer the thread has not reached. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.