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ForumsSemaglutide (Ozempic / Wegovy)Oral semaglutide 25mg vs 50mg — looking for input Page 9

Oral semaglutide 25mg vs 50mg — looking for input

pam_stl Thu, May 30, 2024 at 9:03 AM 55 replies 2,751 viewsPage 9 of 11
Dr.RenalNash
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Jun 20, 2024 at 5:26 PM#41
Dr.NephBHM_UK said:
The mechanism and the magnitude are separate questions.

Coming at Dr.NephBHM_UK’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

24 22wei_SG, cory_ATX, lori_vegas and 21 others
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TrialTracker_MD
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Jun 21, 2024 at 12:58 PM#42

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Jun 21, 2024 at 5:58 PM
25 23stefan_berlin, Dr.EM_Chicago, pete_RVA and 22 others
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mike_mod
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Jun 22, 2024 at 8:29 AM#43

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

26 24DoseLogDan, SleepFixSam, PurityPaulOR and 23 others
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TrialNerd_Beth
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Jun 23, 2024 at 4:00 AM#44
TrialTracker_MD said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

27 0DoseLogDan, SleepFixSam, PurityPaulOR and 24 others
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DeniseRN_TPA
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Jun 23, 2024 at 11:30 PM#45
TrialTracker_MD said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

28 1Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 25 others
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