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ForumsExercise & Body CompositionYoga and GLP-1 — my results so far Page 4

Yoga and GLP-1 — my results so far

SleepDoc_PDX Fri, Oct 18, 2024 at 10:11 PM 35 replies 2,543 viewsPage 4 of 7
TomFromTexas
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Oct 24, 2024 at 8:00 PM#16
ingrid_STO said:
Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months): Metric Baseline Month 3 Month 6 Month 9 Skeletal Muscle (lbs) 76…

Mine went the same way, slower.

22 20PharmD_Rodriguez, julia.endo, JessicaM_2024 and 19 others
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Dr.RaviCardio
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Oct 25, 2024 at 3:49 AM#17

From the other side of the consultation, briefly.

Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the skeletal muscle fiber type distribution:

  • Decreased Type IIx (glycolytic, fast-twitch) fibers
  • Increased Type I (oxidative, slow-twitch) fibers
  • Improved mitochondrial density and function
  • Enhanced insulin-stimulated glucose uptake per fiber

This "metabolic remodeling" of muscle may contribute to improved insulin sensitivity independent of total lean mass changes. The muscle you keep becomes metabolically better, even if there's less of it[1].

References:
[1] Pirkmajer S, et al. Front Physiol. 2023;14:1123456.
23 21anna.melb_AU, mark_tokyo, hans_munich and 20 others
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greg_boulder
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Oct 25, 2024 at 11:38 AM#18
Dr.RaviCardio said:
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…

This matches mine closely enough to be worth saying so out loud.

Last edited: Oct 25, 2024 at 1:38 PM
24 22Dr.DermMIA, fiona_VT, denise_HTX and 21 others
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anna.melb_AU
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Oct 25, 2024 at 7:27 PM#19
Dr.RaviCardio said:
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…

Sharing my comprehensive lab data relevant to lean mass:

BiomarkerBaselineMonth 3Month 6Month 9
Weight (lbs)276246226201
A1C (%)6.66.65.75.3
hsCRP (mg/L)6.04.01.51.2
Triglycerides196146136106

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/week, protein 1.2g/kg/day.

The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.

25 23tammy_FL, Dr.LipidDallas, alex_tucson and 22 others
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mike_mod
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Oct 26, 2024 at 3:16 AM#20

Moderator note: a couple of off-topic posts removed.

Last edited: Oct 26, 2024 at 5:16 AM
47 20PurityPaulOR, MaxMetOK, MounjBrad and 44 others
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