CarlaRPh_TPA said:

Exercise transformation with training: went from barely able to walk a block to completing a 5K last month.

Thank you for spelling out the reasoning rather than just the conclusion.

Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

TinaHashiRN said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.